DMSO Is A Pain Relief

Need Quick Pain Relief? Try DMSO

20 Neck Pain Treatments That Can Help You Find Relief ...When you are in pain, they want relief—and they want it fast. When I was in medical school, one of my professors said, “that a doctor who can’t help relieve a patient’s pain quickly won’t be seeing that patient again.” He was right. That’s why I’m pleased to be able to help patients achieve immediate pain relief for burns, sprains, back pain or arthritis with a little-known favorite remedy called dimethyl sulfoxide (DMSO), a remarkable topical alternative medication for pain that has its own remarkable history. Find out how it can help you…

alt“CONTROVERSIAL” DMSO

The fascinating story of DMSO began in the 1960s, when Stanley Jacob, MD, head of the organ transplant program at Oregon Health Sciences University in Portland, was investigating compounds that might help preserve organs for transplant. DMSO, which had been used as an industrial solvent, attracted his attention because of the way it penetrates skin without damaging it. He experimented with DMSO and found that it could relieve pain.The greatest pain reliever in the world.

The discovery of DMSO inspired the discovery of another related sulfur remedy, methylsulfonylmethane (MSM), a compound with similar pain-relieving effects. I often recommend it be taken orally instead of NSAIDs for pain associated with headaches, fibromyalgia, heartburn and muscle and sports injuries. MSM also is known to ease allergies and asthma.What Causes Neck and Shoulder Pain? ? Excedrin®

From the start, DMSO was highly controversial—and some were worried that this “miracle” drug had harmful side effects, although nothing specific was found. By the mid-1960s, DMSO was a popular product in health-food stores. It was inexpensive—and it worked! The only approval DMSO has received from the FDA is for organ preservation during transplantation and as a local treatment for interstitial cystitis, a painful condition that involves inflammation of the bladder. DMSO is, however, approved for use throughout Canada and Europe as a topical treatment for pain, inflammation, scleroderma (an autoimmune disease of the skin) and arthritis.

It also is widely used by veterinarians to treat animal injuries, especially in horses. If you have never heard of DMSO, I can understand that you may doubt its usefulness, but I know it to be a safe and effective treatment and so do my patients who use it.

Once in a while there comes a natural remedy which is more like a miracle THAN YOU CAN IMAGINE . DMSO or Dimethyl sulfoxide which has gone unnoticed by the medical fraternity despite having properties which are nothing short of being phenomenal. (DMSO has been “unnoticed” or has been covered up by the pharmaceutical companies because it is natural and it works to remove pain.)  Beginning from providing an ease for skin ailments, DMSO has the potential to treat deadly diseases like cancer. The role of DMSO in genetics is significant. DMSO has the miraculous property of protecting animal cells from damage caused by radiation. DMSO has many therapeutic properties related to reduction of trauma in brain injuries. It is an effective free radical scavenger and is an ideal medication for healing brain trauma. Put together, DMSO is surely a wonder drug (natural remedy) which has yet to find the rightful place in the treatment of various illnesses and diseases. Its use can bring down the cost of treatment and also alleviate the pain and trauma caused by illnesses and accident victims.

 

DMSO Works In Different Ways

  1. First, as a topical compound, it has analgesic properties and reduces pain quickly—which is why it is great for rubbing on sore muscles and joints. Laboratory studies suggest that it decreases pain by blocking peripheral nerve C fibers. DMSO reduces inflammation by acting as an antioxidant—and so it neutralizes some of the free radicals that promote inflammation. Some evidence suggests that it also can ease swelling, further helping with aches and pains.

2. Second, DMSO is rich in sulfur—and sulfur is found in every cell and is essential for life. From what we know about DMSO, some of its sulfur is used to create new cells involved in the healing process and in the production of glutathione, the body’s most powerful antioxidant.

3. Third, DMSO dissolves and transports other substances through the skin, which makes it a great carrier and helper in getting other substances into sore or damaged tissues. I have often mixed DMSO with pharmaceutical anti-inflammatory and pain medications, such as ketoprofen (Actron) or gabapentin (Neurotin), so that people can use these combinations topically without damaging the heart and digestive tract. The best way to mix DMSO with drugs is to have a holistic doctor write a prescription for you and to have it made at a compounding pharmacy.

Used in this way, DMSO can provide real relief of symptoms for many conditions, including back pain, severe arthritis of the hands, shingles, severe nerve pain and many other localized problems. It also has been found to promote the healing of leg and foot ulcers and to speed up healing after surgery.

How to use DMSO: Make sure your hands are clean before applying DMSO, especially since it is efficient at transferring substances through the skin. For acute injuries, apply up to four times daily. For chronic conditions, apply twice daily. It can be used for a few days, a few weeks or indefinitely, depending on the condition. Apply a small amount to the painful area and rub it in. Wash your hands after applying DMSO so that excess is not absorbed by your skin.

Within minutes of applying DMSO, many people experience a taste of sulfur or garlic in their mouths that can last for several hours. In general, this is not a big problem. People who are allergic to sulfites can use DMSO. (There is no such thing as an allergy to sulfur.)

Source: Mark A. Stengler, NMD, is a naturopathic medical doctor and leading authority on the practice of alternative and integrated medicine. Dr. Stengler is author of the Health Revelations newsletter, The Natural Physician’s Healing Therapies (Bottom Line Books), and Bottom Line’s Prescription for Natural Cures (Bottom Line Books). He is also the founder and medical director of the Stengler Center for Integrative Medicine in Encinitas, California, and adjunct associate clinical professor at the National College of Natural Medicine in Portland, Oregon. http://MarkStengler.com

Date: August 1, 2011 Publication: Bottom Line Natural Healing

Leg pain

Leg pain

DMSO is used in Painless Products. Experience the fastest pain release in the world!

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MSM #1 – Organic Sulfur- 1/2 lb

MSM Organic Sulfur one half poundProduct Information

Organic sulfur. Pure Methyl-Sulfonyl-Methane also known as Dimethyl-Sulfone. This is the Micro Pro powder without any fillers.  The world’s purest and best selling MSM and the only MSM used in U.S. published clinical research. Others charge $15 to $25 a half pound for this same quality.. 8 oz bag.

  • White crystalline powder, Characteristic bitter taste, Soluble in water. Store in cool and dry place, keep away from strong light and heat.
  • MSM is a source of biological sulfur. Bulk Ingredient for formulation, health finish product R&D, cosmetic product, or any other use purpose.
  • Fresh, 1 to 2.5 years shelf life available.
  • There is not any additive or filler inside.

Click Here to Buy

8 Facts about Sulfur you may not know:

  1. Sulfur (chemical symbol S, atomic number 16) is one of the most important trace minerals on earth (around 5th most important) and is required for food production and a healthy body.
  2. Sulfur is an essential element for all life.
  3. Sulfur is required to regenerate our cells and if our body lacks Sulfur then our cells deteriorate and do not regenerate in a healthy manner, hence we become sick and illnesses such as cancer and heart problems occur.
  4. Since 1954 chemical fertilizers were MANDATED by the US Government. Fertilizers containing ammonium nitrates and sulfates were used by farmers since being MANDATED, however, these fertilizers lack bioavailability and appear to have broken the Sulfur cycle in those countries that use these fertilizers.
  5. Since 1954 the rate of disease in the US has increased by approximately 4,000% (percent) with a resultant decline in health, wealth, mental acuity and quality of life.
  6. A study referred to as “The Sulfur Study” is expected to demonstrate a connection between the lack of Sulfur and the inability of cells to regenerate in a healthy manner. Final results are expected to be released very soon, but preliminary results highlight that all modern diseases can be attributed to mineral deficiencies.
  7. Diseases that never seemed to exist in our Grandparents time now grow at an unprecedented rate and the quality of our food has been greatly diminished.
  8. Our bodies comprise 4% Sulfur but do not store or make Sulfur. We should be getting the Sulfur we need from the foods we eat, however, since 1954 the use of chemical fertilizers has apparently broken the Sulfur cycle.

Organic Sulfur is a critical bio-avalible form of sulfur that has been  missing from our diet since 1954. The introduction of synthetic chemical nitrogen based fertilizers by chemical companies in the 50s has had a profound  negitive effect on our health.  Sulfur and its mineral compounds have been chemically  stripped  from the soils of commercial farming. This has  caused a sulfur deficiency in plants and so in humans and animals,   Our bodies depend on the uptake of bio-avalible sulfur and its related minerals through the eating of  fruits and vegetables. Animals and man don’t store sulfur.

Methylsulfonylmethane (MSM)

The health of the body human is dependant upon all of the minerals which must be bio available and were until we started interrupting the natural cycles of these minerals. Cellular Matrix Study believes the sulfur cycle is broken and until we return to a more organic form of agribusiness we will need to get our sulfur from other sources. Organic Sulfur is the source we are presently researching and in doing so are looking for new members to join our observational study

MSM has been studied for over twenty years at the Oregon Health Sciences University Hospital in Portland, Oregon. In my medical clinic at the University Hospital, I personally have used MSM with thousands of patients in my practice. A few years ago I published my experiences with MSM in my book “The Miracle of MSM. The Natural Solution for Pain”. This book was published in 1999 in the United States. More recently, I have written a comprehensive review of the science and therapeutics of MSM (“MSM, The Definitive Guide”, 2002)  by Stanley W. Jacob, M.D.

  • MSM #1 – Organic Sulfur- 1/2 lb.

    $9.00

  • Product Code:MSMP6

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MSM – Eight Ounce Package of Powder

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Methylsulfonylmethane (MSM), also known as dimethyl sulfone, is an organosulfur compound with the formula (CH3)2SO2.

In more common terms, MSM is a common sulfur element found in many foods. Time and processing diminish the quality of MSM in foods, and in our fast, highly processed world this basic element can become deficient in our diets.

Clinical evidence for MSM usefulness is limited to animal studies and four published clinical studies in humans with the most positive a study in the treatment of osteoarthritis. As reported by Wikipedia:

Osteoarthritis: “After several reports that MSM helped arthritis in animal models, a double-blind, placebo-controlled study suggested that 1500 mg per day MSM (alone or in combination with glucosamine sulfate) was helpful in relieving symptoms of knee osteoarthritis”.

MSM is organic sulfur.  MSM also stands for “Methyl Sulfonyl Methane.”

On this web site you will find several pages about MSM.  You will also find the lowest prices of any of hundreds of web sites offering MSM.  In fact, you can buy wholesale here if you are interested in bulk supplies.

This website serves as a resource for consumers, researchers, medical practitioners and media who want to learn about the science and evidence for MSM.

MSM, methylsulfonylmethane (METH-?l-sul-FON-il-METH-ane) provides sulfur, a vital building block of joints, cartilage, skin, hair and nails, and methyl groups, which support many vital biochemical processes in the body, including energy production. MSM is a naturally-occurring nutrient found in small amounts of many foods.

As a dietary supplement, MSM is synthesized. When made correctly, it is identical to that found in nature. MSM can be taken alone or in combination with other joint health supplements, such as glucosamine and chondroitin.

From experience we have found MSM to be less toxic than water and also you’ll find it is also far less expensive than many nutritional products which do far less good.

WE think of MSM as primarily a cleansing agent, but it is almost more famous for its ability to relieve the pains of arthritis, and reduce scar tissue, etc.

How to take MSM

The cheapest way is in bulk.  You can take it by the teaspoonful — one heaping teaspoon is about 5 grams and some people would encourage you to start small, but build up to about 20 grams per day.

With capsules, I recommend you start with a few, but do not hesitate to get up to 20 or more capsules per day.  You can pull a capsule apart to put the contents into any beverage or to use in other ways.
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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MSM – 8 ounce package

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MSM 8 ounce package is a good deal – MSM … Natural Sulfur Compound Found In All Living Things. Works Wonders For Arthritis, Builds healthy Flexible Cells, and Used For Overall Body Balance.

MSM belongs to a family of compounds that are abundant in the food chains of terrestrial and ocean life. This sulfur-containing nutrient is the stable end product of the methyl-S-methane series of compounds that provide bioavailable sulfur to as many as 85% of all living organisms. These compounds—principally dimethyl sulfide (DMS)—are among the Earth’s few primary sources for sulfur.

The sulfur cycle begins in the ocean, where algae and phytoplankton release sulfur compounds, called tertiary dimethylsulfonium salts. These salts are transformed to DMS, a highly volatile compound. Oceanic DMS is the major natural source of sulfur to the atmosphere and contributes both to the tropospheric sulfur burden and to particle formation and growth in the atmosphere.

MSM Safety

MSM has been shown to be safe by several studies. In thirty years there have been no reported adverse events to MSM. It’s also important to note that sulfa allergies do not apply to MSM.

Some Clinical studies of MMS

Human Clinical Trials
Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonyl-methane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis and Cartilage 2006;14:286-94.
Southwest College Research Institute, Southwest College of Naturopathic Medicine & Health Sciences, Tempe, AZ, USA. [Abstract on PubMed]

In 2004, Kim et al conducted a randomized, double-blind, placebo-controlled clinical trial to evaluate the effects of distilled MSM on mild to moderate osteoarthritis of the knee. Participants received 3,000 mg twice daily of either placebo or MSM (OptiMSM, Bergstrom Nutrition, Vancouver, WA)) for 12 weeks. Patients were evaluated using standardized clinical efficacy scales as well as for several secondary endpoints, adverse events, and clinical laboratory markers. Compared to placebo, those taking MSM had statistically significant reductions in pain and in difficulty performing activities of daily living. Statistically significant reductions in serum homocysteine (a risk factor for cardiovascular disease) and urinary malondialdehyde (a marker of oxidative stress) were also observed. There were no significant adverse events in the study.

Engelke UF, Tangerman A, Willemsen MA, et al. Dimethyl sulfone [MSM] in human cerebrospinal fluid and blood plasma confirmed by one-dimensional (1)H and two-dimensional (1)H-(13)C NMR. NMR Bio Med 2005;18:33l-6.
Radboud University Nijmegen Medical Centre, Laboratory of Pediatrics and Neurology, L-6500 HB Nijmegen, The Netherlands. [Abstract on PubMed]

(1)H-NMR spectroscopy at 500 MHz was used to confirm that a previously unidentified singlet resonance at 3.14 ppm in the spectra of cerebrospinal fluid and plasma samples corresponds to dimethyl sulfone (DMSO(2)). A triple resonance inverse cryogenic NMR probe, with pre-amplifier and the RF-coils cooled to low temperature, was used to obtain an (1)H-(13)C HSQC spectrum of CSF containing 8 microM (753 ng/ml) DMSO(2). The (1)H-(13)C correlation signal for DMSO(2) was assigned by comparison with the spectrum from an authentic reference sample. In plasma and CSF from healthy controls, the concentration of DMSO(2) ranged between 0 and 25 micromol/l. The concentration of DMSO(2) in plasma from three of four patients with severe methionine adenosyltransferase I/III (MAT I/III) deficiency was about twice the maximum observed for controls. Thus, DMSO(2) occurs as a regular metabolite at low micromolar concentrations in cerebrospinal fluid and plasma. It derives from dietary sources, from intestinal bacterial metabolism and from human endogenous methanethiol metabolism. Copyright (c) 2005 John Wiley & Sons, Ltd.

Barrager E, Veltmann JR, Schauss AG, Schiller RN. A multi-centered, open label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J Altern Complement Med 2002;8:167-74.

In a open-label study of 55 patients with seasonal allergic rhinitis (SAR; hayfever), MSM at 2600mg/day significantly reduced upper and total respiratory symptoms within 7 days; lower respiratory symptoms were significantly improved from baseline by week 3. No significant changes were observed in plasma IgE or histamine levels. Few side effects were associated with the use of MSM and no patient dropped out of the study due to adverse reactions. Energy levels increased significantly by day 14. The results suggest that MSM may be an efficacious in reducing symptoms associated with SAR.

Blum JM, Blum RI. The effect of methylsulfonylmethane (MSM) in the control of snoring. Integrative Medicine 2004;3(6)24-30.
Childs SJ. Dimethyl sulfone (DMSO2) in the treatment of interstitial cystitis. Urol Clin North Am 1994;21:85-8.

Dr. Childs presents six case studies on the use of intravesicular MSM for interstitial cystitis in patients who were refractory to previous therapy.

Lawrence RM. Methylsulfonylmethane (M.S.M.) A double-blind study of its use in degenerative arthritis. Int J Anti-Aging Med 1998;1(1):50 [abstract].

In this abstract, Lawrence presented data on a “preliminary study” in which patients suffering from degenerative arthritis were treated with either 2,250 mg per day of MSM (Adaptin, no manufacturer specified) or placebo for an unspecified length of time. Sixteen patients were reportedly enrolled in the study. Eight received MSM and six received placebo. The author does not indicate what treatment, if any, was administered to the two remaining patients. Lawrence reported “a better than 80 percent control of pain within six weeks of beginning the study.” The title of the abstract indicates that a double-blind protocol was followed.

Usha PR, Naidu MUR. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clin Drug Invest 2004; 24:353-63.

Randomized, double-blind trial comparing MSM, glucosamine, both, or placebo for osteoarthritis of the knee. Approximately 30 patients per group. Dose was 1,500 mg per day for 12 weeks. The efficacy parameters studied were the pain index, the swelling index, visual analogue scale pain intensity, 15m walking time, the Lequesne index, and consumption of rescue medicine. There were statistically significant decreases in pain with Glu and with MSM respectively. The combination treatment resulted in a more significant decrease in the mean pain index than either treatment alone. Conclusion: Glu, MSM and their combination produced an analgesic and anti-inflammatory effect in osteoarthritis. Combination therapy showed better efficacy in reducing pain and swelling and in improving the functional ability of joints than the individual agents.

Vidyasagar S, Mukhyaprana P, Shashikiran U,et al. Efficacy and Tolerability of glucosamine chondroitin sulphate – methyl sulfonyl methane (MSM) in osteoarthritis of knee in Indian patients. Iran J Pharmacol Ther 2004;3:61-5.
Isolation; presence in nature, in animals and humans
Pearson TW, Dawson HJ, Lackey HB. Natural occurring levels of dimethyl sulfoxide in selected fruits, vegetables, grains and beverages. J Agric Food Chem 1981; 29:1019-21.

Performed at Crown-Zellerbach, this study documents the presence of MSM (DMSO2; Me2SO2) in asparagus, alfalfa, beets, cabbage, corn, cucumber, oats, swiss chard, tomatoes, apples, raspberry, beer, coffee, milk and tea.

Pfiffner JJ, North HB. Dimethyl sulfone: A constituent of the adrenal gland. J Biol Chem 1940;134:781-2.

From the research labs of Parke-Davis, one of the earliest isolations of dimethyl sulfone (1940). Originally isolated from cattle blood, this study found MSM in fresh beef glands.

Williams KIH, Burstein SH, Layne DS. Dimethyl sulfone: isolation from cows’ milk. Proc Soc Exp Biol Med 1966;122:865-6.

Supported in part by the National Institute of Arthritis and Metabolic Diseases and performed at the Worcester Foundation for Experimental Biology, this study isolated MSM from cow’s milk and noted that urinary excretion of MSM approximated 5-10mg/24 hours in humans.

Williams KIH, Burstein SH, Layne DS. Dimethyl Sulfone:  Isolation from human urine. Arch Biochem Biophys 1966;113:251-2.

MSM is isolated in human urine. In samples from 4 women and 4 men, the rate of excretion varied from 4mg to 11mg. The authors speculate that the MSM excreted may be derived from dietary sources or a product of the metabolism of sulfur containing amino acids.

Williams KIH, Burstein SH, Layne. Metabolism of dimethyl sulfide, dimethyl sulfoxide, and dimethyl sulfone in the rabbit. Arch Biochem Biophys 1966;117:84-7.
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Animal Studies
David Amiel, PhD; Robert M Healey, BS, MBA and Yasushi Oshima, MD, PhD, Assessment of methylsulfonylmethane (MSM) on the development of osteoarthritis (OA): An animal study FASEB J. 2008 22:1094.3.

This study examined the effects of ultra pure methylsulfonylmethane (OptiMSM) on osteoarthritis of the knee. A prior study showed that while OptiMSM is clinically effective, the mechanism remained enigmatic. In this study, the right knee ACL was transected (ACLT) in mature NZW rabbits (n=10) (2). Five weeks after ACLT an MSM constant delivery system to the joint was created by implanting an Alzet osmotic pump. Controls received no other treatment. Animals were sacrificed 9 wks postop, and OA grading of the femoral surface was performed: Grade-I (G-1): intact surface; Grade-II (G-II): minimal fibrillation; Grade-III (G-III): overt fibrillation; and Grade-IV (G-IV): erosion of articular cartilage surface (2). Results showed 2 G-III and 1 G-IV (avg 3.3) in control. The MSM-treated group showed 1 G-I, 3 G-II, 1 G-III, and 2 G-IV (avg 2.6). Expression of type II collagen and aggrecan showed no difference between control and MSM, yet expression of TNF-a in both cartilage and synovial tissue was decreased by MSM (p<0.01). MSM preserved the articular cartilage surface during OA development and reduced inflammation (i.e. TNF-a) in both cartilage and synovium.

Robert A DiSilvestro, David J DiSilvestro, and Daniel J DiSilvestro, Methylsulfonylmethane (MSM) Intake in Mice Produces Elevated Liver Glutathione and Partially Protects Against Carbon Tetrachloride-Induced Liver Injury FASEB J. 2008 22:445.8.

MSM’s antioxidant actions have been proposed based mostly on indirect evidence. For example, antioxidant actions in vivo of a related compound, DMSO, may be produced by MSM formed in vivo from DMSO. Thus, a study was done in mice to determine whether oral intake of OptiMSM could affect tissue levels of an internal sulfur-containing antioxidant, glutathione, and resistance to chemically-induced oxidant stress. MSM administration (5 weeks, 80 mg/100 ml drinking water) produced a statistically significant increase in liver glutathione (mean increase of 78%). A similar effect was not seen in lung or skeletal muscle. In addition, MSM partially inhibited liver injury after injection of carbon tetrachloride, which induces liver oxidant stress (injury evaluation based on blood indexes of hepatic injury). These results indicate the need for further testing for MSM antioxidant actions in vivo, and to explore the mechanism of elevated glutathione.

Magnuson, B.A., Appleton, J., Ryan, B., Matulka, R.A., Oral Developmental Toxicity Study of Methylsulfonylmethane in Rats, Food and Chemical Toxicology (2006), doi: 10.1016/j.fct.2006.12.003

The objective of these studies was to determine the developmental toxicity potential of MSM when administered orally to pregnant rats during the period of major organogenesis and histogenesis. In a preliminary dose-finding study, distilled MSM microprill (i.e., microspherical pellets of MSM) was administered by oral gavage at dose levels of 0 (vehicle control), 50, 250, 500, and 1000 mg/kg/day to 8-9 sperm-positive female Sprague-Dawley rats/group/day on gestation days 6 through 20. No evidence of maternal or fetal toxicity was observed. For the definitive developmental study, four groups of 24-25 timed-bred primiparous female rats were administered 0, 50, 500, or 1000 mg MSM/kg/day via gavage on gestation days 6 through 20. Maternal feed consumption, body weight, body weight gain, uterus weight and corrected body weight/body weight gain were unaffected by treatment. No evidence of maternal toxicity, and no significant differences in litter viability, litter size, or litter body weight were detected. Fetal evaluations failed to show any biologically significant increase in the incidence of anomalies in the MSM treated groups, and no malformations were seen in any of the fetuses. No evidence of fetal mortality, alterations to growth, or structural alterations were observed in the fetuses of dams administered 50 to 1000 mg/kg/day. Therefore, under the conditions of this study, the no-observed-adverse-effect level (NOAEL) for maternal and developmental toxicity was 1000 mg/kg/day.

Magnuson, B.A., Appleton, J., Ames, B.A., Pharmacokinetics and Distribution of [35S]Methylsulfonylmethane following Oral Administration to Rats, Journal of Agricultural and Food Chemistry (2006)

The objective of this study was to evaluate the pharmacokinetic profile and distribution of radiolabeled MSM in rats. Male Sprague-Dawley rats were administered a single oral dose of [35S]MSM (500 mg/kg), and blood levels of radioactivity were determined at different time points for up to 48 h. Tissue levels of radioactivity at 48 and 120 h and urine and fecal radioactivity levels were measured at different time points for up to 120 h following [35S]MSM administration to rats. Oral [35S]MSM was rapidly and efficiently absorbed with a mean tmax of 2.1 h, Cmax of 622 µg equiv/mL, and AUC0-inf of 15124 h.µg equiv/mL. The t1/2 was 12.2 h. Soft tissue distribution of radioactivity indicated a fairly homogeneous distribution throughout the body with relatively lower concentrations in skin and bone. Approximately 85.8% of the dose was recovered in the urine after 120 h, whereas only 3% was found in the feces. No quantifiable levels of radioactivity were found in any tissues after 120 h, indicating complete elimination of [35S]MSM. The results of this study suggest that [35S]MSM is rapidly absorbed, well distributed, and completely excreted from the body.

Richmond VL. Incorporation of methylsulfonylmethane sulfur into guinea pig serum proteins. Life Sci 1986;39:263-8.
Wang M-Y, Anderson G, Nowicki D. Preventive effect of methylsulfonylmethane (MSM) at the induction stage of mammary carcinogenesis induced by DMBA in female SD rats. Proc Am Assoc Cancer Res 2003; 44(8):787 [Abstract #3445].
Wang M-Y, Anderson GL, Nowicki D. Synergistic effect of Tahitian Noni Juice (TNJ) and methylsulfonylmethane (MSM) on mammary breast cancer prevention at the initiation stage of chemical carcinogenesis induced by DMBA in female Sprague-Dawley (SD) rats. Cancer Epidemiol Biomarkers Prev 2003;12:1354S.
Carlson, RP [study director]. Bergstrom Nutrition rat carrageenan air pouch model No. 1. White Eagle Toxicology Laboratories [Unpublished: data on file]. (Sponsored by Bergstrom Nutrition).

Anti-inflammatory actions of MSM observed in an experimental rat study in 2001. MSM compared to indomethacin in a rat carrageenan air pouch model. The objective of the study was to determine whether MSM inhibited leukocyte influx and edema in an acute inflammation model. MSM was administered orally (300 or 1,000 mg/kg for three days) to male CD Charles River rats, in which inflammation was produced with injections of carrageenan.  Oral MSM at 1,000mg/kg, administered for two days prior and up to two hours prior to carrageenan injections inhibited the total number of leukocytes migrating into the pouch at four hours by 26%. The 300mg/kg dose inhibited leukocyte infiltration by 18%. These results did not reach statistical significance, possibly due to the small number of animals studied, or because the anti-inflammatory effects of MSM are more likely to be demonstrated in a chronic inflammation model.

Gerhards E, Gibian H. The metabolism of dimethyl sulfoxide and its metabolic effects in man and animals. Ann N Y Acad Sci 1967;141:65-76.

Metabolism of DMSO, including its oxidation to MSM, in the human. Key factoid: 15% of ingested DMSO is rapidly oxidized to DMSO2 (MSM) in vivo, by hepatic microsomes in the presence of NADPH2 and molecular oxygen.

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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MSM – 16 Ounce package

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MSM 16 Ounce package. This technology ensures the highest quality of MSM on the market to-day, entirely free of any contaminants. The fine crystal powder form of MSM is sometimes preferred by people that like to dissolve the powder in a juice or in water.  Since the crystals are extremely fine, they dissolve quickly.

Here are some Questions and Answers

Few people are sulfur-deficient? Does MSM help?
A:
Most people derive all the sulfur they need from their diet, from the sulfur-containing amino acids cysteine and methionine, which are abundant in animal-derived foods such as meat, eggs, milk and other dairy products.  MSM is not needed to correct sulfur deficiency; it is useful for its own beneficial effects. Theoretically, if someone were deficient in sulfur, MSM could be a reasonably good source.

Does MSM have any proven effects on insulin, blood sugar, blood pressure, or peptic ulcer?
A:
No. Sulfur is a component of many amino acids and hormones, and is required for the production of many more. But just because sulfur is required to produce insulin, it is not correct to believe that taking sulfur as a supplement (e.g., in MSM) would have any effect on the body’s production or secretion of insulin. The regulatory pathways for blood sugar metabolism are far more complex than that.

What are the benefits of MSM over non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen?
A:
MSM is an effective anti-inflammatory agent. Unlike NSAIDs, however, it does not bad side effects such as causing gastritis or inhibit cartilage synthesis.

Can patients with allergies to sulfa drugs still take MSM?
A:
Many patients with allergies to sulfa drugs can take MSM. MSM contains no sulfonamides, and these allergies are not necessarily transferable to all sulfur-containing substances. However, patients with sulfonamide allergies also tend to have other medication allergies as well.

Is MSM safe for pregnant women and/or children?
A:
There are no known reasons why pregnant women and children could not take MSM. However, its safety for these groups has not been definitively proven. As with most nutritional supplements, MSM should not be taken by pregnant women or children unless prescribed by a qualified doctor. Research is currently underway to determine the safety of MSM for these groups of people.

Does MSM have any proven effects on insulin, blood sugar, blood pressure, or peptic ulcer?
A:
No. Sulfur is a component of many amino acids and hormones, and is required for the production of many more. But just because sulfur is required to produce insulin, it is not correct to believe that taking sulfur as a supplement (e.g., in MSM) would have any effect on the body’s production or secretion of insulin. The regulatory pathways for blood sugar metabolism are far more complex than that. These FAQ’s are from http://www.msmguide.com/msm-practitioner/faq/

How is MSM made? MSM is made from DMSO (Dimethyl Sulfoxide), and DMSO is made by processing the waste product (trees) of paper making (“pulp and paper industry”)– it is NEVER made by simply processing trees or any other form of plant life (no matter what you might read in some less informed Internet sources), for the sole purpose of extracting DMSO. It COULD be, just as sea water could be used for the sole purpose of extracting gold, but this is totally impractical.

In paper making — DMSO is extracted from the waste product of paper making — and it is the PAPER MAKING that allows the whole process to be practical. As paper is made, the paper is made of the fibers of wood. But, as trees grow, the fibers of wood are stuck together, in the living tree, by a substance called “lignin.” Lignin is like a glue that holds the fibers together. The wood could not be made into paper if all the fibers are still stuck together — so in paper making it must include some process by which the lignin is removed, allowing the wood fibers to be managed into flat paper, etc.

Lignin is removed with something called “pulping chemicals.” These chemicals are sodium sulfite (the majority), sodium sulfide and sodium carbonate). When these chemicals are soaked in a vat with wood chips, the lignin dissolves and the wood fibers can then be removed from the mass. Generally about 50% of the stuff in the vat would be the wood fibers, ready for making into paper, and 50% would be the residue, the waste product, of the original “pulping chemicals” and the lignin that has now been dissolved. That first liquid is called DMS (CH3 – S – CH3), but it quickly and easily further refined into DMSO.

DMSO is the main ingredient from which MSM is made by a controlled oxidation process using hydrogen peroxide (H2O2) and water. There are no other chemicals used, and the H2O2 is turned into water.

It is very important to realize that if you purchase MSM, then the MSM you receive has been distilled. NO CHEMICALS ARE LEFT BEHIND. It is the purest possible form of the chemical MSM and is made in one of the two factories in the USA.

DMSO by itself is a great health tool and it is also sold on this website.


This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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